Receptors and crosspresentation in dendritic cells journal of. Crosspresentation of cellassociated antigens by mhc. Adjuvants enhancing crosspresentation by dendritic cells. Two human immunodeficiency virus vaccinal lipopeptides follow. The primary and most efficient crosspresenting cells are dendritic cells, though. Plasmacytoid dendritic cells pdcs play a crucial role in initiating immune responses by secreting large amounts of type i ifns. The ability to crosspresent has been thought of as a feature of specialized dc subsets.
Dendritic cells are the professional apcs of our immune system that are key in. What links here related changes upload file special pages permanent link page information. Pdf crosspresentation by dendritic cells researchgate. Crosspresentation by dendritic cells 491 internalized into cells of the dc lineage either through cd4 and the coreceptors ccr5 or cxcr4, but also through dcsign for interstitial. In the cytosolic pathway, exogenous antigens are translocated from endosomal compartments into the cytosol for degradation by the proteasome. Molecular mechanisms of dendritic cell crosspresentation. Publication processes organization and format errata, author corrections, retractions. Antigen crosspresentation describes the process through which dendritic cells dcs acquire exogenous antigens for presentation on mhc class i molecules. Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen crosspresentation and. In vivo, cross presentation is mainly carried out by specific dendritic cell dc subsets through an. In vivo, crosspresentation is mainly carried out by specific dendritic cell dc subsets through an. As a model to study crosspresentation pathways in dendritic cells, we have previously. Antigen crosspresentation by dendritic cell subsets.
Current concepts of antigen crosspresentation ncbi. Adjuvants enhancing crosspresentation by dendritic cells frontiers. Crosspresentation is the ability of certain antigenpresenting cells to take up, process and. Thesestudiessupporttheviewthat, under certain circumstances, speci. Dendritic cells dcs have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can. We discuss a the antigenic requirements for crosspresentation, b the phenotype of the antigen presenting cell apc, c the cellular interactions and molecular signals involved in crosspriming, and d the factors that direct the immune system toward tolerance or immunity. Dcs are especially known for their ability to crosspresent, as they process and present exogenous antigens on mhci molecules much more efficiently than other phagocytes.
Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex mhc i molecules. Dendritic cellmediated antigen presentation initiates specific immune responses. Molecular mechanisms of dendritic cell crosspresentation dendritic cells are the professional apcs of our immune system that are key in linking innate and adaptive immunity. Limited proteolysis in the endocytic compartments of dendritic cells dcs favours crosspresentation by preventing the destruction of internalized antigens. Targeting uptake receptors on human plasmacytoid dendritic.
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